In a laboratory study, Comfortis started to kill fleas within 30 minutes and killed 100% of the fleas within 4 hours. Hematology and clinical chemistry values were compared pre- and post-study and were unremarkable. Two cats that received extra-label topical otic ivermectin on Day -1 of the field study developed lethargy on Day 1 after Comfortis administration on Day 0. Key Benefits. Comfortis Chewable Tablets for Dogs and Cats Rx (1219 Reviews) Write a Review Ask a Question Share: This Item Ships FREE! By day 24, ALT values had returned to near baseline levels. Spinosad contains two major factors, spinosyn A and spinosyn D, derived from the naturally occurring bacterium, Saccharopolyspora spinosa. Other common side effects in cats include diarrhoea and loss of appetite. Comfortis for Dogs & Cats requires a prescription from your veterinarian. Copyright 2023 PetMed Express, Inc. All Rights Reserved. You should discuss the use of Comfortis with your veterinarian prior to use in breeding females. Does seeing fleas on my dog mean that the flea treatment is not working? Overall winner is Comfortis Comfortis not only kills fleas but works as a preventative that will continue to keep your dog safe from fleas. This number represents the amount of PetMeds Points you will receive by purchasing this item. Spinosad does not interact with known insecticidal binding sites of other nicotinic or GABAergic insecticides such as neonicotinoids, fiproles, milbemycins, avermectins, and cyclodienes. The safe use of Comfortis in breeding, pregnant, or lactating cats and dogs has not been evaluated. Best all-around preventative: Advantage Multi Topical Solution. For dogs: The most common adverse reaction reported is vomiting. What if I give more than the prescribed amount of Comfortis to my dog? Its the brand trusted by veterinarians, prescribed more than 90 million times.5. There are 2 great ways to buy and I would recommend based off your circumstances: Comfortis . If a dose is missed, administer Comfortis with food and resume a monthly dosing schedule. Principal Display Panel 810 mg Box Label. Other adverse reactions reported in decreasing order of frequency are: depression/lethargy, decreased appetite, incoordination, diarrhea . Cheapest way to buy Comfortis for cats - The Kitty Expert NDC 0986-4221-06 CA4221 Comfortis is a chewable, beef-flavored tablet that kills fleas and prevents flea infestations in dogs for one month. for cats; the other is Capstar Flea Control Tablets. MAX PET SUPPLIES PTY LTD. ABN: 86 603 803 738. Post approval experience continues to support the safety of Comfortis when used concurrently with heartworm preventatives according to label directions. Oral flea and tick preventatives for dogs are becoming more popular among veterinarians and dog lovers, but each dog and dog parent has unique needs or issues. In US and European field studies, no dogs experienced seizures when dosed with Comfortis at the therapeutic dose range of 13.5-27.3 mg/lb (30-60 mg/kg), including 4 dogs with pre-existing epilepsy. Key points of your discussion may include the following: Give Comfortis with food for maximum effectiveness. Starts killing fleas within 30 minutes; Lasts a full month Many of the owners on the thread as quite upset by some also offer some alternatives that you could try. Is Comfortis Discontinued? However, there are also numerous additional effective products available that your veterinarian may recommend for dog flea protection. Phospholipidosis (vacuolation) of the lymphoid tissue was seen in all dogs treated with Comfortis, the long-term effects of which are unknown. Product guarantee Elanco Animal Health stands behind Comfortis (spinosad). Cancel or update at anytime. Comfortis was tested in pure and mixed breeds of healthy dogs in well-controlled clinical and laboratory studies. Your email address will not be published. Female fleas that are living on animals produce eggs that fall from the animal into their surroundings. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/AnimalVeterinary/SafetyHealth. Short answer, no, no comparison at all. Comfortis kills fleas before they can lay eggs when used monthly according to the label directions. Give Comfortis to your cat once a month. Continue giving Comfortis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, incoordination, weight loss, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Traffic still remains more leisure-driven and the heavy limitations that are still stifling demand on international routes affect traffic flows . Spinosyn A and spinosyn D have the chemical compositions 2-[(6-deoxy-2,3,4 tri-O-methyl--L-mannopyranosyl)oxy]-13- [[5 (dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]- 9 ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16btetradecahydro- 14-methyl-1H-as-indaceno[3,2-d] oxacyclododecin-7,15-dione and 2-[(6-deoxy-2,3,4-tri-Omethyl- -L-mannopyranosyl)oxy] 13-[[5-(dimethylamino) tetrahydro-6-methyl-2H-pyran-2 yl]oxy]-9-ethyl-2,3,3a,5a,5b, 6,9,10,11,12,13,14,16a,16b tetradecahydro-4,14-dimethyl- 1H-as-indaceno[3,2 d]oxacyclododecin-7,15-dione, respectively. The long term effects of phospholipidosis are unknown. Comfortis is the only other oral flea medication for cats. They both come in the form of a convenient, chewable tablet. In well-controlled field studies, Comfortis was administered safely in conjunction with other frequently used veterinary products, such as vaccines, anthelmintics, antibiotics, steroids, flea and tick control products, anesthetics, NSAIDs, antihistamines, alternative/herbal remedies, shampoos, and prescription diets. Puncture Here, Principal Display Panel - 560 mg Carton Label, Principal Display Panel 560 mg Box Label, Principal Display Panel - 810 mg Blister Label, Comfortis (spinosad) Following concomitant extra-label use of ivermectin with Comfortis, some dogs have experienced the following clinical signs: trembling/twitching, salivation/drooling, seizures, ataxia, mydriasis, blindness and disorientation. Comfortis chewable tablets may be chewed, offered in food, or administered like other tablet medications. 8:578. The primary target of action of Comfortis in insects is an activation of nicotinic acetylcholine receptors (nAChRs). Alternatively, Comfortis may be offered in food or administered like other tablet medications. Additional information can be found at www.Comfortis.com. For dogs: The most common adverse reaction reported is vomiting. Or how about an alternative oral flea medicine for cats that is effective? Use with caution in breeding females. For heartworm prevention, use products that are specifically prescribed by your veterinarian. 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All you need to apply is to have a debit or credit card, to be over 18 years of age, and to be a resident of Australia. trembling/twitching, salivation/drooling, seizures, ataxia, mydriasis, blindness and disorientation. digest Comfortis, they will die from hyperexcitation. Safety was shown in cats and kittens 14 weeks of age and older, in multiple laboratory studies and a field study in household cats. Schedule, update or cancel anytime, Reliable Comfortis Flea Tablet for Cats - Vet Review in 2023 Does seeing fleas on my cat mean that the treatment is not working? Important Information Best price guarantee across a huge range of COMFORTIS-DISCONTINUED with free, fast shipping. Comfortis was not associated with clinically significant changes in hematology, clinical chemistry, coagulation or urinalysis parameters. Credelio for Dogs Credelio is a one-of-a-kind tick and Prolonged spinosad-induced hyperexcitation results in prostration, paralysis, and flea death. [Find Alternatives]. Comfortis for Dogs: Uses, Dosage, Side Effects - Drugs.com Cloudflare Ray ID: 7c09fb910d5f387f If vomiting occurs within one hour of administration, redose with another full dose. 4. Some limitations and restrictions may apply. Spinosyn A and spinosyn D have the chemical compositions 2-[(6-deoxy-2,3,4-tri-Omethyl- -L mannopyranosyl)oxy]-13-[[5-dimethylamino)- tetrahydro-6 methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b, 6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl- 1H-as Indaceno[3,2-d]oxacyclododecin-7, 15-dione and 2-[(6-deoxy 2,3,4-tri-O-methyl--L-mannopyranosyl)oxy]- 13-[[5 dimethylamino)-tetrahydro-6-methyl-2H-pyran-2-yl] oxy]-9 ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a, 16b tetradecahydro-4,14-dimethyl-1H-as-Indaceno[3,2-d] oxacyclododecin-7,15-dione, respectively. Store at 20-25C (68 -77F), excursions permitted between 15 to 30C (59 to 86F). Comfortis may be chewed, offered in food, or administered like other tablet medications: 12.1-24 lbs (Green Box) Give one 560 mg chewable tablet by mouth once a month. Amazon.com: Comfortis The average daily and total weight gains of treated dogs were smaller than control dogs and were dose dependent. Insurance Mobile Apps GoodRx Prescription Discount Card Drugs A-Z Drugs by . Comfortis is the first FDA-approved, chewable beef-flavored tablet (derived from pork protein and hydrolyzed soy) that kills fleas and prevents flea infestations on dogs and cats for a full month. Buy Discount Trifexis for Dogs Online $68.95/6pk | petimeds